Purine nucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF232, OSBPL7, and FCRLB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF232 grouped by Purine nucleoside metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF232 →	-1.872	-1.194	.001	.001	3	4
KIDNEY	OSBPL7 →	+0.719	+0.674	.009	.003	3	3
CNS	FCRLB →	+0.711	+1.125	.003	<.001	3	3
CNS	DENND5A →	+0.490	+0.992	.009	.002	3	3
LIVER	RRP9 →	-0.616	-0.937	<.001	.004	3	3
OESOPHAGUS	SLC35G2 →	+1.943	+1.522	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF232 by Purine nucleoside metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →