Purine nucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACROD1, SINHCAF, and GRN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside metabolic process activity versus MACROD1 in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MACROD1 →	+1.370	+1.539	.007	.001	2	7
BONE	SINHCAF →	+1.054	+1.450	.002	.001	3	5
LARGE_INTESTINE	GRN →	-1.014	-1.128	.004	<.001	3	4
BONE	EDN1 →	-2.949	-1.595	.005	<.001	3	4
STOMACH	ACYP1 →	+1.273	+1.297	<.001	<.001	3	4
BLOOD_Leukemia	MAPKAPK5 →	+0.558	+0.462	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042278 vs MACROD1 — STOMACH

Explore this scatter interactively →