Error-prone translesion synthesis

Across TCGA patient cohorts, RNA activity of the Error-prone translesion synthesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMAD4, TPX2_S486, and HPF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Error-prone translesion synthesis activity versus SMAD4 in HNSC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMAD4 →	+0.278	+0.076	<.001	.001	3	6
LUAD	TPX2_S486 →	+1.399	+0.066	<.001	<.001	3	6
GBM	HPF1 →	+0.290	+0.046	<.001	<.001	3	6
LUAD	PRC1_T481 →	+0.874	+0.038	<.001	<.001	3	6
LUAD	WDHD1 →	+0.573	+0.047	<.001	<.001	3	6
GBM	CSE1L →	+0.279	+0.067	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042276 vs SMAD4 — HNSC

Explore this scatter interactively →