Error-prone translesion synthesis

Across TCGA cell cohorts, RNA activity of the Error-prone translesion synthesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN52, SKAP1, and RAB13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIN52 grouped by Error-prone translesion synthesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LIN52 →	-1.031	-0.415	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SKAP1 →	-0.136	-0.338	.003	.001	2	5
SOFT_TISSUE	RAB13 →	-1.167	-0.353	<.001	.005	3	4
SOFT_TISSUE	MARS2 →	+0.579	+0.273	.009	.007	3	4
BREAST	KRR1 →	-0.680	-0.241	.001	.002	3	4
BREAST	APOBEC3C →	+2.702	+0.285	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIN52 by Error-prone translesion synthesis activity — BLOOD_Myeloma

Explore this box plot interactively →