Ribosomal small subunit biogenesis

Across TCGA patient cohorts, RNA activity of the Ribosomal small subunit biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, SMC1A, and TPR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit biogenesis activity versus RPRD2 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPRD2 →	+0.271	+0.024	<.001	<.001	3	7
LSCC	SMC1A →	+0.205	+0.043	<.001	<.001	3	6
LSCC	TPR →	+0.182	+0.039	<.001	<.001	3	6
LSCC	BRD4 →	+0.224	+0.042	<.001	<.001	3	6
LSCC	DEK →	+0.279	+0.043	<.001	<.001	3	6
GBM	TMF1_T401 →	-0.266	-0.025	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042274 vs RPRD2 — BRCA

Explore this scatter interactively →