Ribosomal small subunit biogenesis

Across TCGA patient cohorts, RNA activity of the Ribosomal small subunit biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC2, CENPH, and LMOD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit biogenesis activity versus XRCC2 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XRCC2 →	+1.009	+0.297	<.001	<.001	3	9
LSCC	CENPH →	+0.599	+0.250	<.001	<.001	3	9
OV	LMOD1 →	-1.346	-0.367	<.001	<.001	3	9
LUAD	CCNB1 →	+0.944	+0.289	<.001	<.001	3	9
BRCA	NUF2 →	+0.931	+0.289	<.001	<.001	3	9
LUAD	ABCA6 →	-0.841	-0.351	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042274 vs XRCC2 — BRCA

Explore this scatter interactively →