Ribosomal small subunit biogenesis

Across TCGA cell cohorts, RNA activity of the Ribosomal small subunit biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HGD, NCSTN, and PPP1R3B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal small subunit biogenesis activity versus HGD in LUNG_NSCLC_LUAD (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HGD →	-1.732	-0.158	.005	.002	2	7
URINARY_TRACT	NCSTN →	-0.806	-0.211	.001	.006	3	5
PANCREAS	PPP1R3B →	-1.217	-0.351	<.001	<.001	3	5
BREAST	NAT1 →	-1.274	-0.104	.002	.003	3	5
STOMACH	RPS27L →	-1.462	-0.177	.001	.001	2	5
BONE	MCEE →	-0.942	-0.285	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042274 vs HGD — LUNG_NSCLC_LUAD

Explore this scatter interactively →