Ribosomal large subunit biogenesis

Across TCGA patient cohorts, RNA activity of the Ribosomal large subunit biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPUSD2, TRMT6, and DHX30, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit biogenesis activity versus RPUSD2 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPUSD2 →	+0.223	+0.095	<.001	<.001	3	7
LSCC	TRMT6 →	+0.360	+0.044	<.001	<.001	3	7
LSCC	DHX30 →	+0.180	+0.049	<.001	<.001	3	6
LSCC	URB2 →	+0.243	+0.042	<.001	<.001	3	6
LSCC	ZC3H8 →	+0.562	+0.045	<.001	<.001	3	6
HNSC	BYSL →	+0.268	+0.097	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042273 vs RPUSD2 — UCEC

Explore this scatter interactively →