Ribosomal large subunit biogenesis

Across TCGA cell cohorts, RNA activity of the Ribosomal large subunit biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNDC11, SCARB2, and LMO7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit biogenesis activity versus TXNDC11 in OVARY (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TXNDC11 →	-0.837	-0.252	<.001	<.001	3	7
PANCREAS	SCARB2 →	-1.207	-0.241	<.001	.004	3	6
SKIN	LMO7 →	-1.802	-0.243	<.001	<.001	3	6
SKIN	YPEL3 →	-1.373	-0.233	.002	.001	3	6
LUNG_NSCLC_LUAD	CD63 →	-0.842	-0.223	.001	.006	3	6
LARGE_INTESTINE	NOP2 →	+0.888	+0.187	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042273 vs TXNDC11 — OVARY

Explore this scatter interactively →