Ribosomal large subunit biogenesis

Across TCGA cell cohorts, RNA activity of the Ribosomal large subunit biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BOP1, GNL3, and PES1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit biogenesis activity versus BOP1 in BLOOD_Myeloma (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	BOP1 →	+1.054	+0.326	<.001	<.001	3	20
LIVER	GNL3 →	+1.436	+0.472	<.001	<.001	3	20
LIVER	PES1 →	+1.420	+0.498	<.001	<.001	3	20
URINARY_TRACT	RPL7L1 →	+1.234	+0.381	.001	<.001	3	20
LIVER	NOP16 →	+1.208	+0.344	.004	.009	3	19
LUNG_NSCLC_LUSC	RRP15 →	+1.574	+0.431	.001	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042273 vs BOP1 — BLOOD_Myeloma

Explore this scatter interactively →