DNA protection

Across TCGA patient cohorts, RNA activity of the DNA protection pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1, CH25H, and HPGDS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA protection activity versus CYP1B1 in OV (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYP1B1 →	-1.282	-0.121	.003	.006	3	4
OV	CH25H →	-0.809	-0.143	.006	.004	3	4
LSCC	HPGDS →	-0.511	-0.323	.003	.002	3	4
UCEC	DDX21 →	+0.485	+0.416	<.001	.004	3	4
OV	ABHD4 →	-0.724	-0.181	.006	.001	3	3
OV	SAMHD1 →	-0.451	-0.116	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042262 vs CYP1B1 — OV

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