DNA protection

Across TCGA cell cohorts, RNA activity of the DNA protection pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT7, HUNK, and CYFIP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA protection activity versus KRT7 in BREAST (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRT7 →	-3.858	-0.903	<.001	.001	3	6
BLOOD_Lymphoma	HUNK →	+0.857	+0.212	.002	.006	3	5
BLOOD_Leukemia	CYFIP2 →	+3.304	+0.695	.001	.006	3	5
BLOOD_Leukemia	BCL7A →	+1.237	+0.509	.004	.003	3	5
LUNG_NSCLC_LUAD	METTL9 →	+0.586	+0.985	.008	.009	2	5
BLOOD_Lymphoma	IFI44 →	-3.693	-0.271	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042262 vs KRT7 — BREAST

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