Cytosolic ribosome assembly

Across TCGA patient cohorts, RNA activity of the Cytosolic ribosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFL1, MAP2K1, and C15orf40, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytosolic ribosome assembly activity versus EFL1 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EFL1 →	+0.396	+0.063	<.001	<.001	3	9
BRCA	MAP2K1 →	+0.208	+0.037	<.001	<.001	3	7
COAD	C15orf40 →	+0.310	+0.026	.002	.009	3	6
COAD	RPUSD2 →	+0.406	+0.043	.004	<.001	3	6
LSCC	FAM98B →	+0.186	+0.040	<.001	<.001	3	6
COAD	FBXO22 →	+0.228	+0.029	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042256 vs EFL1 — OV

Explore this scatter interactively →