Cytosolic ribosome assembly

Across TCGA cell cohorts, RNA activity of the Cytosolic ribosome assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX3X, CLASP1, and TIGAR, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX3X grouped by Cytosolic ribosome assembly-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DDX3X →	-0.572	-0.303	<.001	<.001	3	12
LUNG_NSCLC_LUSC	CLASP1 →	+0.186	+0.149	.002	.003	3	5
SKIN	TIGAR →	-0.095	-0.153	.008	.004	3	4
LUNG_NSCLC_LUAD	EYA4 →	-0.136	-0.230	.008	.008	3	4
BLOOD_Leukemia	ENTPD7 →	+0.157	+0.142	.008	.003	3	4
BONE	RPS8 →	+0.164	+0.172	.009	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX3X by Cytosolic ribosome assembly activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →