Ribosome assembly

Across TCGA patient cohorts, RNA activity of the Ribosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX47, ESF1, and NCL_S619, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome assembly activity versus DDX47 in BRCA (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX47 →	+0.395	+0.029	<.001	.001	3	6
LSCC	ESF1 →	+0.350	+0.046	<.001	<.001	3	6
BRCA	NCL_S619 →	+0.398	+0.022	<.001	.004	3	6
PDAC	NSUN5 →	+0.286	+0.026	<.001	.002	3	6
LSCC	DDX56 →	+0.361	+0.047	<.001	<.001	3	6
BRCA	NOL10 →	+0.423	+0.028	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042255 vs DDX47 — BRCA

Explore this scatter interactively →