Ribosome assembly

Across TCGA patient cohorts, RNA activity of the Ribosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA5, CDC6, and TIMELESS, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome assembly activity versus CDCA5 in LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDCA5 →	+1.089	+0.292	<.001	<.001	3	9
LUAD	CDC6 →	+1.183	+0.241	<.001	<.001	3	9
LUAD	TIMELESS →	+0.655	+0.237	<.001	<.001	3	9
BRCA	MYBL2 →	+2.015	+0.424	<.001	<.001	3	8
BRCA	FOXM1 →	+1.042	+0.271	<.001	<.001	3	8
LUAD	RAD51AP1 →	+0.708	+0.205	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042255 vs CDCA5 — LUAD

Explore this scatter interactively →