Ribosome assembly

Across TCGA cell cohorts, RNA activity of the Ribosome assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNG3, ZNF76, and NAA50, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNG3 grouped by Ribosome assembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KCNG3 →	-0.549	-0.816	.007	<.001	3	6
BLOOD_Myeloma	ZNF76 →	-0.627	-0.664	.002	<.001	3	5
BLOOD_Lymphoma	NAA50 →	+0.522	+0.722	<.001	<.001	3	5
BLOOD_Lymphoma	LRRCC1 →	-0.330	-0.750	.007	<.001	3	5
SKIN	PARM1 →	+0.261	+0.134	<.001	.004	2	6
SKIN	MAGEH1 →	+0.201	+0.378	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNG3 by Ribosome assembly activity — BLOOD_Lymphoma

Explore this box plot interactively →