Ribosome assembly

Across TCGA cell cohorts, RNA activity of the Ribosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF3, FAM83G, and LGALS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF3 grouped by Ribosome assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF3 →	-0.947	-0.273	.008	.008	3	5
BONE	FAM83G →	+1.761	+0.256	.004	.006	3	4
LUNG_NSCLC_LUSC	LGALS1 →	+5.239	+0.226	.003	.003	3	4
BLOOD_Leukemia	EPB41 →	-1.315	-0.262	.009	.002	3	4
BLOOD_Leukemia	PMM1 →	+1.216	+0.328	<.001	<.001	3	4
BLOOD_Leukemia	PPP1R8 →	-0.581	-0.253	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF3 by Ribosome assembly activity — OESOPHAGUS

Explore this box plot interactively →