Ribosome assembly

Across TCGA cell cohorts, RNA activity of the Ribosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HARS1, WRAP53, and PGAP3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome assembly activity versus HARS1 in URINARY_TRACT (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HARS1 →	+0.595	+0.171	.004	.007	3	8
BREAST	WRAP53 →	+0.908	+0.189	.001	<.001	3	6
LARGE_INTESTINE	PGAP3 →	-0.723	-0.108	.007	.002	3	6
PANCREAS	FAM216A →	+1.617	+0.169	.001	.005	3	6
LUNG_NSCLC_LUAD	PRRG2 →	-1.772	-0.221	<.001	<.001	3	6
PANCREAS	TMEM45B →	-3.631	-0.218	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042255 vs HARS1 — URINARY_TRACT

Explore this scatter interactively →