Tissue regeneration

Across TCGA patient cohorts, RNA activity of the Tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NISCH, LINC01894, and FAM53B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tissue regeneration activity versus NISCH in PDAC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NISCH →	+0.232	+0.140	.004	<.001	3	4
CCRCC	LINC01894 →	+0.084	+0.131	.008	.008	3	3
UCEC	FAM53B →	+0.559	+0.171	.001	<.001	3	3
PDAC	CDKL2 →	-0.328	-0.178	.003	.005	3	3
PDAC	SKA1 →	-0.489	-0.173	.007	.006	3	3
PDAC	CDC25C →	-0.348	-0.126	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042246 vs NISCH — PDAC

Explore this scatter interactively →