Tissue regeneration

Across TCGA cell cohorts, RNA activity of the Tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA2, TRIM37, and ARHGAP32, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCA2 grouped by Tissue regeneration-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ABCA2 →	-1.152	-1.207	.008	.006	3	2
SOFT_TISSUE	TRIM37 →	+0.490	+0.927	.002	.005	3	2
SOFT_TISSUE	ARHGAP32 →	-1.041	-1.182	.008	.005	3	2
BONE	INTS6L →	-1.908	-1.537	<.001	.003	3	2
SOFT_TISSUE	DOLPP1 →	+0.722	+1.431	.002	.001	3	2
SOFT_TISSUE	RNASEH1 →	-0.821	-1.181	<.001	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCA2 by Tissue regeneration activity — SOFT_TISSUE

Explore this box plot interactively →