Tissue regeneration

Across TCGA cell cohorts, RNA activity of the Tissue regeneration pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOCS2, MYL12A, and TTC22, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MOCS2 grouped by Tissue regeneration-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MOCS2 →	+0.153	+0.166	.003	.003	3	3
URINARY_TRACT	MYL12A →	-0.280	-0.346	.003	.001	3	2
URINARY_TRACT	TTC22 →	+0.180	+0.276	<.001	.001	3	2
LUNG_NSCLC_LUAD	ETV2 →	+0.097	+0.211	.009	.004	3	2
LUNG_NSCLC_LUAD	GINS2 →	-0.268	-0.192	.006	<.001	3	2
LUNG_NSCLC_LUAD	NTMT1 →	-0.103	-0.232	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MOCS2 by Tissue regeneration activity — SKIN

Explore this box plot interactively →