Response to cocaine

Across TCGA patient cohorts, RNA activity of the Response to cocaine pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDH13, HSPG2, and SERPINF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cocaine activity versus CDH13 in CCRCC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDH13 →	-0.434	-0.035	.002	.001	3	6
CCRCC	HSPG2 →	-0.335	-0.037	<.001	.006	3	6
CCRCC	SERPINF1 →	-0.846	-0.049	<.001	<.001	3	5
CCRCC	TBX2_S360 →	-0.530	-0.034	<.001	.007	3	5
PDAC	VCL_S290 →	-1.002	-0.033	<.001	.002	3	5
CCRCC	FERMT2 →	-0.386	-0.048	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042220 vs CDH13 — CCRCC

Explore this scatter interactively →