Response to cocaine

Across TCGA patient cohorts, RNA activity of the Response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf115, MMP17, and KHDRBS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cocaine activity versus C1orf115 in GBM (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C1orf115 →	+1.162	+0.232	<.001	<.001	3	4
GBM	MMP17 →	+0.769	+0.178	.005	.002	3	4
LUAD	KHDRBS3 →	+0.770	+0.297	<.001	.002	3	3
HNSC	NPTX2 →	+0.686	+0.304	.005	.006	3	3
PDAC	DAP3 →	-0.273	-0.755	.005	.002	3	3
GBM	TXN →	-0.539	-0.250	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042220 vs C1orf115 — GBM

Explore this scatter interactively →