Response to cocaine

Across TCGA cell cohorts, RNA activity of the Response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NHS, C18orf32, and SYVN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NHS grouped by Response to cocaine-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NHS →	+1.605	+0.391	<.001	.009	3	4
SKIN	C18orf32 →	+0.689	+0.348	.006	.004	3	3
LUNG_NSCLC_LUSC	SYVN1 →	+0.696	+0.209	.001	<.001	3	3
BLOOD_Leukemia	POLR2C →	-0.677	-0.381	.002	<.001	3	3
BLOOD_Leukemia	CNOT1 →	-0.560	-0.333	.003	.004	3	3
BLOOD_Leukemia	LPAR2 →	+1.263	+0.336	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NHS by Response to cocaine activity — LUNG_SCLC

Explore this box plot interactively →