Response to cocaine

Across TCGA cell cohorts, RNA activity of the Response to cocaine pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEK2, TGM2, and BEND3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cocaine activity versus PLEK2 in OVARY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLEK2 →	+2.614	+0.271	.001	<.001	3	5
OVARY	TGM2 →	+3.653	+0.215	<.001	<.001	3	5
OVARY	BEND3 →	-0.921	-0.251	<.001	.001	3	4
LIVER	SNX10 →	-2.305	-0.332	<.001	.007	3	4
OVARY	DNMT3A →	-1.388	-0.251	.004	.009	3	4
OVARY	GYG2 →	-1.911	-0.209	.008	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042220 vs PLEK2 — OVARY

Explore this scatter interactively →