Cellular modified amino acid catabolic process

Across TCGA patient cohorts, RNA activity of the Cellular modified amino acid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPSM3, THEMIS2, and MYO1F, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular modified amino acid catabolic process activity versus GPSM3 in HNSC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GPSM3 →	-0.453	-0.069	<.001	<.001	3	6
HNSC	THEMIS2 →	-0.294	-0.049	<.001	.001	3	6
LSCC	MYO1F →	-0.240	-0.039	.004	<.001	3	6
GBM	SASH3 →	-0.437	-0.033	<.001	<.001	3	5
LSCC	TBXAS1 →	-0.458	-0.053	<.001	<.001	3	5
GBM	TCEA3_S115 →	+0.852	+0.035	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042219 vs GPSM3 — HNSC

Explore this scatter interactively →