Cellular modified amino acid catabolic process

Across TCGA patient cohorts, RNA activity of the Cellular modified amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMCN, GSPT2, and FOSB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular modified amino acid catabolic process activity versus EMCN in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EMCN →	+0.919	+0.336	<.001	<.001	3	4
BRCA	GSPT2 →	+0.574	+0.172	.001	.003	3	4
BRCA	FOSB →	+1.275	+0.257	<.001	<.001	3	4
BRCA	ACACB →	+0.912	+0.211	<.001	.002	3	4
GBM	NPHP1 →	+0.440	+0.176	.006	.001	3	4
GBM	AQP1 →	+1.490	+0.205	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042219 vs EMCN — BRCA

Explore this scatter interactively →