Ketone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ketone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL10P12, C12orf45, and VIRMA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone biosynthetic process activity versus RPL10P12 in OV (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL10P12 →	+1.086	+0.198	.008	.003	3	4
GBM	C12orf45 →	-0.304	-0.165	.008	<.001	3	4
GBM	VIRMA →	-0.146	-0.138	.004	.001	3	4
GBM	LINC02803 →	-0.543	-0.208	<.001	<.001	3	4
BRCA	APH1A →	-0.410	-0.196	<.001	<.001	3	3
BRCA	TARDBP →	-0.210	-0.117	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042181 vs RPL10P12 — OV

Explore this scatter interactively →