Ketone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ketone biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HES3, S100A1, and TIE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HES3 grouped by Ketone biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HES3 →	-0.164	-1.068	.003	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	S100A1 →	-0.391	-1.250	.004	.007	3	6
LIVER	TIE1 →	-0.208	-1.196	<.001	.005	2	6
PANCREAS	PRKCI →	+0.193	+0.918	.001	<.001	3	5
LUNG_NSCLC_LUAD	ESR1 →	-0.113	-0.895	.003	<.001	3	5
LUNG_SCLC	CD5 →	+0.221	+1.478	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HES3 by Ketone biosynthetic process activity — BREAST

Explore this box plot interactively →