Ketone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ketone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP4, TMEM101, and COX17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARP4 grouped by Ketone biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PARP4 →	-1.317	-0.676	.001	.005	3	5
BREAST	TMEM101 →	-1.301	-0.912	.003	.001	3	5
LUNG_NSCLC_LUSC	COX17 →	+1.166	+1.170	.002	.006	2	5
LUNG_NSCLC_LUSC	PLCG2 →	-1.136	-1.091	<.001	<.001	3	4
PANCREAS	DCAKD →	-0.739	-1.027	.004	.007	3	4
PANCREAS	PLCXD2 →	-2.091	-1.220	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP4 by Ketone biosynthetic process activity — BREAST

Explore this box plot interactively →