Ketone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ketone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF738, SDF2, and NUDT22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone biosynthetic process activity versus ZNF738 in BLOOD_Lymphoma (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF738 →	-2.236	-0.226	.003	.006	3	5
URINARY_TRACT	SDF2 →	+0.647	+0.255	.005	.008	3	4
BONE	NUDT22 →	+1.200	+0.490	.001	<.001	3	4
SOFT_TISSUE	DDB2 →	+1.273	+0.257	.007	.002	3	4
PANCREAS	CXXC1 →	-1.115	-0.207	.003	.005	3	4
SOFT_TISSUE	TBX20 →	-1.000	-0.284	<.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042181 vs ZNF738 — BLOOD_Lymphoma

Explore this scatter interactively →