Xenobiotic catabolic process

Across TCGA cell cohorts, RNA activity of the Xenobiotic catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRI3BP, UNG, and RAB22A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRI3BP grouped by Xenobiotic catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	BRI3BP →	-1.622	-0.712	.005	.003	3	5
LIVER	UNG →	-0.951	-0.683	.007	.008	3	5
LUNG_NSCLC_LUSC	RAB22A →	+0.988	+1.966	<.001	<.001	3	4
LUNG_SCLC	SPTLC2 →	-1.050	-0.498	<.001	.002	3	4
LUNG_SCLC	PDS5A →	-0.793	-0.451	.003	.009	3	4
LUNG_SCLC	RASSF7 →	-1.096	-0.410	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRI3BP by Xenobiotic catabolic process activity — LIVER

Explore this box plot interactively →