Negative regulation of protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2_S351, EIF3K, and FBLN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein catabolic process activity versus FERMT2_S351 in PDAC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FERMT2_S351 →	+0.734	+0.025	.002	<.001	3	5
OV	EIF3K →	-0.148	-0.022	.007	.005	3	5
BRCA	FBLN5 →	+0.823	+0.029	<.001	<.001	3	5
BRCA	HAPLN3 →	+0.509	+0.025	.007	<.001	3	5
CCRCC	RPL27A →	-0.427	-0.029	<.001	<.001	3	5
GBM	MAP2_S1155 →	+0.538	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042177 vs FERMT2_S351 — PDAC

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