Negative regulation of protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDFIP2, HINT2, and WDR77, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDFIP2 grouped by Negative regulation of protein catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NDFIP2 →	+1.034	+0.320	.001	.003	3	5
KIDNEY	HINT2 →	-0.706	-0.226	.005	.002	3	4
CNS	WDR77 →	-0.655	-0.222	<.001	.001	3	4
URINARY_TRACT	STIP1 →	-0.844	-0.290	.001	.001	3	4
URINARY_TRACT	WRAP53 →	-1.076	-0.290	<.001	.001	2	5
STOMACH	MRPL24 →	-0.693	-0.143	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDFIP2 by Negative regulation of protein catabolic process activity — KIDNEY

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