Negative regulation of protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVIL, HSPE1, and CENPO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein catabolic process activity versus AVIL in BLOOD_Myeloma (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	AVIL →	-1.242	-0.159	.003	.001	3	6
PANCREAS	HSPE1 →	+0.907	+0.316	<.001	<.001	3	5
PANCREAS	CENPO →	+0.987	+0.255	<.001	<.001	3	5
PANCREAS	C4orf46 →	+1.010	+0.321	.002	<.001	3	5
LIVER	DDX1 →	+0.734	+0.189	.003	.006	3	5
LIVER	PFDN6 →	+0.486	+0.226	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042177 vs AVIL — BLOOD_Myeloma

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