Lipoprotein catabolic process

Across TCGA patient cohorts, RNA activity of the Lipoprotein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE2J2, CDK7_S164, and CNRIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein catabolic process activity versus UBE2J2 in BRCA (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UBE2J2 →	-0.460	-0.040	<.001	<.001	3	4
LUAD	CDK7_S164 →	-0.513	-0.040	.006	.003	3	4
BRCA	CNRIP1 →	+0.410	+0.036	<.001	<.001	3	4
BRCA	DDX55 →	-0.184	-0.038	.009	<.001	3	4
OV	EPB41L3 →	+0.643	+0.059	.002	.002	3	4
BRCA	AKAP12_S627 →	+0.775	+0.053	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042159 vs UBE2J2 — BRCA

Explore this scatter interactively →