Lipoprotein catabolic process

Across TCGA patient cohorts, RNA activity of the Lipoprotein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB3, CACYBP, and CD244, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein catabolic process activity versus HMGB3 in HNSC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HMGB3 →	-0.848	-0.104	.004	.002	3	5
LSCC	CACYBP →	-0.741	-0.115	<.001	.005	3	5
LSCC	CD244 →	+0.556	+0.151	<.001	<.001	3	5
LSCC	WDFY4 →	+0.697	+0.106	<.001	<.001	3	5
LSCC	GMFG →	+0.630	+0.114	<.001	<.001	3	5
LSCC	CD72 →	+0.629	+0.122	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042159 vs HMGB3 — HNSC

Explore this scatter interactively →