Lipoprotein catabolic process

Across TCGA patient cohorts, RNA activity of the Lipoprotein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LIPA, ARHGAP9, and ATM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein catabolic process activity versus LIPA in BRCA (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LIPA →	+0.498	+0.108	<.001	<.001	3	4
GBM	ARHGAP9 →	+0.348	+0.084	<.001	<.001	3	4
GBM	ATM →	+0.217	+0.091	.001	.001	3	4
PDAC	CD53 →	+0.435	+0.142	.001	.001	3	4
GBM	CIT →	-0.464	-0.097	<.001	<.001	3	4
GBM	DOCK2 →	+0.427	+0.082	.002	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042159 vs LIPA — BRCA

Explore this scatter interactively →