Lipoprotein catabolic process

Across TCGA cell cohorts, RNA activity of the Lipoprotein catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALOX15P1, BTN3A1, and AMELX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALOX15P1 grouped by Lipoprotein catabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ALOX15P1 →	+0.274	+0.248	.004	.005	2	5
SOFT_TISSUE	BTN3A1 →	-0.287	-0.199	.007	.009	2	5
SOFT_TISSUE	AMELX →	-0.273	-0.249	.002	<.001	3	4
LARGE_INTESTINE	RASAL2 →	+0.145	+0.153	.002	.009	3	4
BLOOD_Myeloma	NFKBIB →	+0.403	+0.441	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	MPP6 →	+0.256	+0.301	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALOX15P1 by Lipoprotein catabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →