Lipoprotein catabolic process

Across TCGA cell cohorts, RNA activity of the Lipoprotein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD8, CCDC88A, and ACOT4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein catabolic process activity versus BTBD8 in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BTBD8 →	+1.006	+0.314	.002	.009	2	6
LIVER	CCDC88A →	-1.208	-0.326	.007	.003	3	4
BREAST	ACOT4 →	+1.780	+0.185	.001	.003	3	4
URINARY_TRACT	PGAP1 →	+1.567	+0.320	.004	.005	3	4
LUNG_SCLC	COQ8A →	+1.218	+0.228	.005	.002	3	4
STOMACH	WDR26 →	+0.941	+0.276	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042159 vs BTBD8 — STOMACH

Explore this scatter interactively →