Lipoprotein biosynthetic process

Across TCGA patient cohorts, RNA activity of the Lipoprotein biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL6, and RPL18A_S123, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein biosynthetic process activity versus RPL5 in GBM (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.242	-0.049	<.001	<.001	3	7
GBM	RPL6 →	-0.521	-0.047	.001	.001	3	7
HNSC	RPL18A_S123 →	-0.268	-0.040	.001	.002	3	7
PDAC	SLC39A14 →	-0.359	-0.020	.001	.009	3	6
GBM	HYI →	+0.363	+0.045	<.001	<.001	3	6
BRCA	SEC24A →	-0.239	-0.025	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042158 vs RPL5 — GBM

Explore this scatter interactively →