Lipoprotein biosynthetic process

Across TCGA patient cohorts, RNA activity of the Lipoprotein biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WARS2-IT1, RHOJ, and LINC00710, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein biosynthetic process activity versus WARS2-IT1 in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WARS2-IT1 →	-0.229	-0.192	.006	.002	3	4
PDAC	RHOJ →	-0.373	-0.275	.001	<.001	3	4
PDAC	LINC00710 →	-0.170	-0.170	.003	.008	3	4
GBM	KIAA0930 →	+0.514	+0.142	<.001	.001	3	4
HNSC	MPZL2 →	+0.892	+0.184	<.001	<.001	3	3
CCRCC	SEPTIN4 →	-0.639	-0.218	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042158 vs WARS2-IT1 — BRCA

Explore this scatter interactively →