Lipoprotein biosynthetic process

Across TCGA cell cohorts, RNA activity of the Lipoprotein biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1D, SPAG7, and NDUFAB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EEF1D grouped by Lipoprotein biosynthetic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EEF1D →	-0.764	-0.913	.004	.005	3	4
CNS	SPAG7 →	+0.668	+0.935	.002	.003	3	4
BREAST	NDUFAB1 →	+0.583	+0.864	.001	.001	3	4
LUNG_NSCLC_LUAD	H1-3 →	+0.302	+0.909	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SSU72 →	-0.996	-1.320	.002	.002	3	3
OVARY	MAT2A →	+0.671	+0.941	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EEF1D by Lipoprotein biosynthetic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →