Lipoprotein biosynthetic process

Across TCGA cell cohorts, RNA activity of the Lipoprotein biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP12, ZNF226, and SMARCA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein biosynthetic process activity versus ARHGAP12 in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARHGAP12 →	-0.569	-1.051	.001	.001	3	4
SKIN	ZNF226 →	-0.539	-0.902	.006	.005	3	4
SKIN	SMARCA2 →	-0.739	-0.849	.001	.009	3	4
LIVER	PTBP3 →	+0.820	+1.270	.004	.009	3	4
OVARY	UPF3A →	+0.818	+1.008	.003	.007	3	4
KIDNEY	RAP2B →	-0.794	-1.711	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042158 vs ARHGAP12 — LUNG_SCLC

Explore this scatter interactively →