Lipoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUCLG2, CHCHD4, and ACD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein metabolic process activity versus SUCLG2 in LUNG_SCLC (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SUCLG2 →	-1.401	-0.249	<.001	.009	3	6
STOMACH	CHCHD4 →	-1.039	-0.280	<.001	.002	3	5
URINARY_TRACT	ACD →	-0.792	-0.316	.002	.008	3	5
OVARY	SNTA1 →	-1.455	-0.264	.005	<.001	3	4
BLOOD_Myeloma	TSKU →	-1.794	-0.254	.002	<.001	3	4
BREAST	SLC25A46 →	-0.668	-0.226	.002	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042157 vs SUCLG2 — LUNG_SCLC

Explore this scatter interactively →