Cellular response to glucose starvation

Across TCGA patient cohorts, RNA activity of the Cellular response to glucose starvation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPSTI1_S35, RPL5, and RRP12_S1080, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to glucose starvation activity versus EPSTI1_S35 in OV (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EPSTI1_S35 →	+1.773	+1.343	<.001	.001	3	3
GBM	RPL5 →	+0.185	+0.111	.001	.002	2	3
OV	RRP12_S1080 →	+0.660	+0.805	.001	.001	3	2
GBM	SFSWAP_S832 →	+0.742	+0.136	<.001	<.001	3	2
COAD	TSR1 →	+0.235	+0.173	<.001	.009	3	2
CCRCC	YARS1 →	+0.206	+0.213	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042149 vs EPSTI1_S35 — OV

Explore this scatter interactively →