Cellular response to glucose starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to glucose starvation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBXN6, CRTC1, and CAPN12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBXN6 grouped by Cellular response to glucose starvation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBXN6 →	-0.327	-0.367	.006	.007	3	5
BLOOD_Lymphoma	CRTC1 →	-1.257	-0.502	.003	<.001	3	4
OESOPHAGUS	CAPN12 →	-1.711	-0.186	.003	.006	3	4
SKIN	NECAP1 →	-0.512	-1.099	.008	.006	3	4
LUNG_SCLC	TMEM81 →	+0.678	+0.204	<.001	.001	3	3
LUNG_SCLC	ADO →	+0.827	+0.261	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBXN6 by Cellular response to glucose starvation activity — LARGE_INTESTINE

Explore this box plot interactively →