Cellular response to glucose starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to glucose starvation pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXF2, HSD3B1, and BTF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXF2 grouped by Cellular response to glucose starvation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FOXF2 →	-0.224	-0.104	.001	<.001	3	5
LUNG_SCLC	HSD3B1 →	-0.257	-0.065	.001	.008	3	5
LUNG_SCLC	BTF3 →	-0.359	-0.077	.005	<.001	3	5
URINARY_TRACT	UBE2V1 →	-0.519	-0.108	.003	.009	3	4
SKIN	TMEM8B →	+0.458	+0.064	.002	.002	3	4
BREAST	FOXE3 →	+0.117	+0.032	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXF2 by Cellular response to glucose starvation activity — URINARY_TRACT

Explore this box plot interactively →