"Retrograde transport, endosome to Golgi"

Across TCGA patient cohorts, RNA activity of the "Retrograde transport, endosome to Golgi" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTN1, LRPPRC, and APOE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Retrograde transport, endosome to Golgi" activity versus RTN1 in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RTN1 →	+0.544	+0.036	.002	.001	2	7
COAD	LRPPRC →	-0.369	-0.024	<.001	<.001	3	6
CCRCC	APOE →	+0.611	+0.025	.005	.002	3	6
LSCC	VIM →	+0.316	+0.029	<.001	.004	3	6
GBM	MAP1A →	+0.340	+0.035	<.001	<.001	3	6
COAD	SLIRP →	-0.428	-0.023	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042147 vs RTN1 — GBM

Explore this scatter interactively →